From the diary of Samuel Pepys (1663-1703)
To the Crowne tavern behind the Exchange by appointment, and there met the first meeing of Gresham College since the plague. Dr. Goddard did fill us with talk in defence of his and his fellow-physicians' going out of town in the plague-time; saying that their perticular patients were most gone out of town, and they left at liberty---and a great deal more, etc. But what, among other fine discourse, pleased me most, was Sir G. Ent about Respiration; that it is not to this day known or concluded on among physicians, nor to be done either, how that action is managed by nature or for what use it is. -- Pepys' Diary, 22 Jan. 1666